B complex is generally used in Phase I Liver detoxification (cytochrome P450 Enzymes). Typically B vitamins should be given in combination as they work synergistically.

The liver plays several roles in detoxification: it filters the blood to remove large toxins, synthesizes and secretes bile full of cholesterol and other fat-soluble toxins, and enzymatically disassembles unwanted chemicals. This enzymatic process usually occurs in two steps referred to as phase I and phase II. Phase I either directly neutralizes a toxin, or modifies the toxic chemical to form activated intermediates which are then neutralized by one of more of the several phase II enzyme systems.

Vitamin B12 is an essential vitamin that’s crucial for many vital metabolic and hormonal functions — including the production of digestive enzymes and carrying important nutrients into and out of cells. Due to how it helps convert and synthesize many other compounds within the body, it’s needed for well over 100 daily functions. Some of the roles that are attributed to vitamin B12 include: red blood cell production, DNA/RNA synthesis, methylation and producing the coating of the nerves.

Calcium is the most abundant mineral in the body, with 99% residing in bones and teeth. As a component of hard tissues, Calcium fulfills a structural role to maintain body size and act as attachments for musculoskeletal tissues. The remaining 1% of calcium is present in blood and soft tissues. Functions of non-skeletal Calcium include: enzyme activation, blood clotting, cell and cell organelle membrane function (stabilization and transport), nerve impulse transmission, and muscular contraction, tone, and irritability. Calcium levels in the blood are maintained within very strict limits by dietary intake, hormonal regulation, and a rapidly exchangeable pool in bone tissue.

Magnesium is the fourth most abundant mineral in the human body. It plays several important roles in the health of your body and brain. It is a mineral found in the earth, sea, plants, animals, and humans. About 60% of the magnesium in your body is found in bone, while the rest is in muscles, soft tissues, and fluids, including blood.

Every cell in your body contains it and needs it to function. One of Magnesium's main roles is acting as a cofactor or helper molecule in the biochemical reactions continuously performed by enzymes. In fact, it's involved in more than 600 reactions in your body.

Vitamin C is a potent reducing agent, meaning that it readily donates electrons to recipient molecules. Related to this oxidation-reduction (redox) potential, two major functions of vitamin C are as an antioxidant and as an enzyme cofactor.

Vitamin C is the primary water-soluble, non-enzymatic antioxidant in plasma and tissues. Even in small amounts Vitamin C can protect indispensable molecules in the body, such as proteins, lipids (fats), carbohydrates, and nucleic acids (DNA and RNA), from damage by free radicals and reactive oxygen species (ROS) that are generated during normal metabolism, by active immune cells, and through exposure to toxins and pollutants (e.g., certain chemotherapy drugs and cigarette smoke). Vitamin C also participates in redox recycling of other important antioxidants; for example, Vitamin C is known to regenerate Vitamin E from its oxidized form.

Vitamin C’s role as a cofactor is also related to its redox potential. By maintaining enzyme-bound metals in their reduced forms, vitamin C assists mixed-function oxidases in the synthesis of several critical biomolecules. Symptoms of vitamin C deficiency, such as poor wound healing and lethargy, result from impairment of these enzymatic reactions and insufficient collagen, carnitine, and catecholamine synthesis.

Vitamin C affects several components of the human immune system; for example, vitamin C has been shown to stimulate both the production and function of leukocytes (white blood cells), especially neutrophils, lymphocytes, and phagocytes. Specific measures of functions stimulated by vitamin C include cellular motility, chemotaxis, and phagocytosis. Neutrophils, mononuclear phagocytes, and lymphocytes accumulate vitamin C to high concentrations, which can protect these cell types from oxidative damage. In response to invading microorganisms, phagocytic leukocytes release non-specific toxins, such as superoxide radicals, hypochlorous acid ("bleach"), and peroxynitrite; these reactive oxygen species kill pathogens and, in the process, can damage the leukocytes themselves. Vitamin C, through its antioxidant functions, has been shown to protect leukocytes from self-inflicted oxidative damage. Phagocytic leukocytes also produce and release cytokines, including interferons, which have antiviral activity. Vitamin C has been shown to increase interferon levels in vitro.